Vagus Nerve Prolonged Stimulation in Cats: Effects on Epileptogenesis (Amygdala Electrical Kindling): Behavioral and Electrographic Changes
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چکیده
منابع مشابه
Ganaxolone suppression of behavioral and electrographic seizures in the mouse amygdala kindling model.
Ganaxolone (3alpha-hydroxy-3beta-methyl-5alpha-pregnan-20-one), a synthetic analog of the endogenous neurosteroid allopregnanolone and a positive allosteric modulator of GABAA receptors, may represent a new treatment approach for epilepsy. Here we demonstrate that pretreatment with ganaxolone (1.25-20 mg/kg, s.c.) causes a dose-dependent suppression of behavioral and electrographic seizures in ...
متن کاملInhibitory effects of succinic acid on chemical kindling and amygdala electrical kindling in rats.
AIM To investigate the effects and mechanism of succinic acid on pentylenetetrazol (PTZ) chemical kindling and amygdala electrical kindling in rats. METHODS PTZ chemical kindling and amygdala electrical kindling models were established in rats. The effects of succinic acid on the behavior and afterdischarge of kindled rats were observed. The mice were pretreated with succinic acid, 30 min lat...
متن کاملEffects of short and prolonged transcutaneous vagus nerve stimulation on heart rate variability in healthy subjects.
The vagus nerve is strategically located in the body, and has multiple homeostatic and health-promoting effects. Low vagal activity predicts onset and progression of diseases. These are the reasons to activate this nerve. This study examined the effects of transcutaneous vagus nerve stimulation (t-VNS) on a main index of vagal activity, namely heart rate variability (HRV). In Study 1, we compar...
متن کاملLow Frequency Electrical Stimulation Either Prior to Or after Rapid Kindling Stimulation Inhibits the Kindling-Induced Epileptogenesis
Objective. Studies are ongoing to find appropriate low frequency stimulation (LFS) protocol for treatment of epilepsy. The present study aimed at assessing the antiepileptogenesis effects of LFS with the same protocol applied either just before or immediately after kindling stimulations. Method. This experimental animal study was conducted on adult Wistar rats (200 ± 20 g) randomly divided into...
متن کاملVagus nerve stimulation for treatment-resistant depression: behavioral and neural effects on encoding negative material.
OBJECTIVES Vagus nerve stimulation (VNS) can improve depression. Cognitive models of depression highlight an over-representation of negative thoughts and memories, with depressed individuals showing memory facilitation for negative material. We hypothesized that the antidepressant action of VNS may emerge through corrective influences on 'negativity bias' in memory. We therefore examined the im...
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ژورنال
عنوان ژورنال: Epilepsia
سال: 1999
ISSN: 0013-9580,1528-1167
DOI: 10.1111/j.1528-1157.1999.tb00787.x